Loading a profile is not a good practice. It was, when it was developed, but since then many-many new features came into the program, like plugins, macroloops, etc. If you load a profile then you replace the environment under all of these stuff.
Instead of loading a profile, make a shortcut to start UCCNC with the wanted profile. Make a copy of the original shortcut, rename it as you want, then rigth-click, properties and after the .exe write /p yourprofilename. E.g.:
- profile.png (1022 Bytes) Viewed 3444 times
(If the profile name contains space then use quotes: /p "My profile".)