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I try to run the AXBB-E on a new Windows 10/64 with Mach3.
When starting Mach3, I get the "plugin defective" message.
The plugin was installed plugin with the UCx00 plugin installer.
The .net framework 4.8 in Windows is enabled.
What else can I try?

Enable the .net framework 3.5 in the Windows features and reboot Windows.
.net 4.8 is not backwards compatible with the .net framework 3.5.

Enable the .net framework 3.5 in the Windows features and reboot Windows.
.net framework 4.8 is not backwards compatible with the .net framework 3.5.